Cancer Research UK
Job DescriptionCancer Research UK-AstraZeneca Antibody Alliance Laboratory: Scientist/Senior ScientistApply (by clicking the related button) after checking via all of the associated job data under.- Protein Sciences Location : Granta Park, Cambridge Contract : 12-month Fixed time period, Full Time (35 hours per week) Salary: £28,000- £42,000 Closing date: Midnight 24 January 2021.Please don’t delay making use of as we will likely be shortlisting on software.Application course of: CV and software questions by way of our careers web page You can discover out extra concerning the position and AstraZeneca Antibody Alliance Laboratory in our candidate pack Are you a self-motivated and focussed particular person with expertise of drug discovery, in a Protein Science-related self-discipline who may help us beat most cancers sooner? In collaboration with AstraZeneca, Cancer Research UK (CRUK) has established a pioneering laboratory in Cambridge.The lab deploys leading edge applied sciences as a way to generate candidate therapeutics, diagnostics and reagent instruments.This thrilling enterprise takes AstraZeneca’s main discovery applied sciences and mix them with organic targets arising from CRUK’s intensive community of educational investigators.Why we’d like you? We are actually searching for a analysis scientist with expertise of drug discovery to play a pivotal position within the protein science operate of the Alliance Laboratory.The put up holder will likely be a part of a multi-disciplinary analysis group focussed on figuring out and characterising biotherapeutic candidates to oncology targets and driving onward improvement to preclinical proof of idea.What will I be doing? * Generating key protein reagents associated to oncology targets for the Laboratory * Troubleshooting protein expression and purification in each mammalian and non-mammalian expression programs * Using an AKTA and different automated purification platforms.As effectively as different analytical strategies similar to SDS-PAGE, HPLC and Western blotting.* Efficiently tackling molecular biology challenges, together with cloning from cDNA.* Undertaking the cautious QC evaluation of targets and antibody reagents for Drug Discovery * Flexibly approaching work, with the capability to prioritise aims in accordance with mission wants * Building wonderful working relationships inside a laboratory and exterior companions What expertise do I would like? * Significant expertise of how one can specific and purify proteins from quite a lot of expression hosts and vectors.* Knowledge of how finest to design and construct protein expression vectors to precise human proteins.* Experience with aseptic approach for culturing of cell strains.* Experience of troubleshooting expression of difficult proteins.* Excellent communication expertise and the flexibility to speak throughout scientific disciplines.* Understanding of biotherapeutic candidate discovery, ideally antibodies, and the general improvement course of for biotherapeutic medicine.What expertise can I carry? * Understanding of biotherapeutic candidate discovery, ideally antibodies, and the general improvement course of for biotherapeutic medicine.* Specialised biophysical characterisation of proteins and their interactions similar to round dichromism, thermal soften curves, isothermal calorimetry and mass spectrometry * Experience of performing affinity measurements of protein-protein interactions, and information of automation processes.* Knowledge of the setup and working of recombinant protein exercise assays * Knowledge of the setup and working of excessive throughput cell-based assays What will I acquire? Without you we would not be capable to obtain our goal of seeing three in four folks survive most cancers by 2034.So, we wish to reward you in as some ways as doable.* There’s loads of profession development and coaching alternatives, via inside and exterior L&D.* 25, days annual go away (plus financial institution holidays and the flexibility to purchase as much as 5 days every year) and 1 CRUK day.* Pension (employer contributions of as much as 10%), life insurance coverage and an excellent profit low cost platform.If you are as bold and passionate as we’re, be part of our collective drive and luxuriate in a superb profession, as we save lives and add years.