Research Scientist II - Find My Rizq

Vertex UK Int'l HQ/R&D

The in vitro human illness modelling staff are searching for an progressive and enthusiastic Research Scientist with experience in utilizing human iPSCs and different mammalian cell techniques to mannequin human illness for HTS, goal and biomarker discovery and compound MoA research. This place will contain working cross-functionally with different researchers and scientific disciplines with the intention to handle elementary physiological questions which underpin our drug discovery efforts, that are globally aligned however regionally carried out throughout the Vertex UK analysis website. With an emphasis on tackling causal biology with the intention to make transformative therapies for sufferers, this place is well-placed to generate, combine, and reap the benefits of human illness mannequin techniques for drug discovery and validation.Key responsibilitiesDesign, conduct, analyse, and interpret experiments utilizing human iPSC derived fashions and different mammalian cell fashions for drug discovery and validation.Mammalian cell tradition, manipulation, and maintenancePreparation of DNA, RNA, protein, and different materials from mobile fashions (for each particular assays and hypothesis-generating experiments)Molecular biology methods together with genotyping, PCR, and cloningGene expression approaches together with qPCRIn vitro phenotyping strategies together with Western Blot, ELISA, FACS, ICC, IF and different mobile assaysSub-cellular protein localisation assays utilizing western blot through Co-IP and biotinylationStudying the results of CRISPR engineered cells carrying disease-associated variantsThe set up- and use of advanced mobile assays which reliably recapitulate human illness together with use of gene enhancing methods similar to CRISPRAssess and introduce state-of-the-art molecular and mobile biology strategies, each to unlock novel hypotheses, and make sure the division stays on the forefront of cutting-edge technologiesAnalyse and draw conclusions from experimental knowledge, each independently and as a part of a larger staff of researchersCollaborate extensively and work on shared initiatives with different scientific colleagues and cross-functional groups, together with others within the Biology Dept and pastConceive, articulate, and execute a lean however highly-informative plan of labor which offers speedy cease/go selections on novel hypotheses and targetsEmbrace and embody an entrepreneurial spirit to search out progressive options to advanced organic issues – empowered decision-making constructed on accountability and scientific excellenceQualifications/ExperiencePh.D. with related moist lab expertise in molecular and cell biology, human physiology, or a associated disciplineExtensive expertise of utilizing cell techniques to search out novel biology, ideally in a drug discovery contextComprehensive moist lab experience within the preparation and use of mammalian cells and stem cellsStrong want to stay ‘fingers on’ on the scientific benchMotivated and curious; pleased to work throughout a broad vary of organic topics and initiatives with the intention to determine the molecular drivers of illness#LI-JR1

Tagged as: engineer, IT, research

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